Chemotherapy induced mucositis
About chemotherapy induced mucositis
Mucositis is the painful inflammation and ulceration of the mucous membranes lining the digestive tract, usually as an adverse effect of chemotherapy and radiotherapy treatment for hepatitis and cancer.
How holvita™ colostrum can help with chemotherapy induced mucositis
Current regimens for the treatment of cancers require patients to take much higher doses of chemotherapeutic agents than were used previously. As a result of these higher doses, toxic adverse effects on the bone marrow and gastrointestinal tract can be the factor limiting the dose or duration of treatment. Strategies to protect these tissues and encourage their recovery may facilitate the use of higher doses of chemotherapy, with greater potential for cure. For example, EGF enhances the repair of rat intestinal mucosa damaged by methotrexate (83), TGF-ß ameliorates chemotherapy-induced mucositis (84), and administration of a cheese whey–derived preparation reduces methotrexate-induced gut injury in mice (85).
Not all studies have shown favorable results, however, because EGF had only a minor beneficial effect in reducing mouth ulceration in a phase I clinical study of patients undergoing chemotherapy (86).
If peptides with growth stimulatory or inhibitory effects are to be used, the timing of administration is likely to be critical; growth-arresting factors might protect bone marrow or gut from the damaging effects of chemotherapy, which tend to affect areas with the highest cell turnover, if given before chemotherapy. In contrast, growth-stimulating factors might "rescue" recovery of injured areas if administered after chemotherapy. This latter approach is already being used clinically, eg, colony-stimulating growth factor is being used to stimulate bone marrow recovery after chemotherapy.
Our holvita colostrum has been proved to be of benefit to people on chemotherapy to reduce side effects such as mucositis and keep the blood picture values within the normal range. (see here for cancer therapy support)
References
83. Hirano M, Iweakiri R, Fujimoto K, et al. Epidermal growth factor enhances repair of rat intestinal mucosa damaged after oral administration of methotrexate. J Gastroenterol 1995;30:169–76.[Medline]
84. Sonis ST, Lindquist L, Van Vugt A, et al. Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3. Cancer Res 1994;54:1135–8.[Abstract]
85. Howarth GS, Francis GL, Cool JC, Ballard RW, Read LC. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 1996;126:2519–30.[Medline]
86. Gordler NM, McGurk M, Aqual S, Prince M. The effect of EGF mouthwash on cytotoxic-induced oral ulceration. Am J Clin Oncol 1995;18:403–6.[Medline]
Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.
Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
Bioactive components for the treatment of gastroinstwestinal disorders Author(s): Ghosh S, Playford RJ. Clinical Science (London, England : 1979). 2003 June; 104(6): 547-56. Review.