Colostrum and Inflammatory bowel disease
About inflammatory bowel disease (IBD)
Inflammatory bowel diseas is a disorder in which the intestines become inflamed (red and swollen), it should not be confused with irritable bowel syndrome (IBS). There are two major types of the disorder, ulcerative colitis (UC) and Crohn disease (CD). Ulcerative colitis is limited to the colon (the large intestine) and Crohn disease can involve any part of the gastrointestinal tract from the mouth to the anus but it most commonly affects the small intestine and/or the colon.
Signs and symptoms
People with inflammatory bowel disease may experience these symtoms;
- Abdominal cramps
- Diarrhoea
- Fever
- Weight loss (poor nutrition intake)
How holvita™ colostrum can help with IBD
For such IBD symptoms, the growth factors contained in the colostrum stimulate the intestinal cells to repair themselves through proliferation and restitution.
"The etiology of ulcerative colitis and Crohn disease is unknown and, therefore, current treatment of these severe, incapacitating conditions has to be on an empirical basis. Studies examining the effect of administration of EGF, PDGF, TGF-ß or IGF-I in animal models of colitis have had encouraging results (87), and a cheese whey growth factor extract containing several of these growth factors had positive results in a similar model (88). Other peptides, not present in milk or colostrum in significant concentrations, under study as potential therapeutic agents for these conditions include keratinocyte growth factor (89) and trefoil peptides (90). These studies are in the very early (animal model) stages and the agents are unlikely to be in standard clinical use for many years. Milk-derived products are already in clinical use for the treatment of inflammatory bowel disease; casein-based enteral feeds are used for the treatment of Crohn disease and their efficacy might be due, in part, to the presence of MDGFs in the preparation, which are preserved during the processing of the milk protein (see above). In addition, clinical trials of the use of colostrum enemas for the treatment of ulcerative colitis and resistant proctitis are under way and the results are awaited with interest." American Journal of Clinical Nutrition (Playford RJ, July 2000)
References
87. Procaccino F, Reinshagen M, Hoffman P, et al. Protective effect of epidermal growth factor in an experimental model of colitis. Gastroenterology 1994;107:12–7.[Abstract]
88. Porter SN, Howarth GS, Butler RN. An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats. Scand J Gastroenterol 1998;33:967–74.[Medline]
89. Zeeh JM, Procaccino F, Hoffmann P, et al. Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. Gastroenterology 1996;110:1077–83.[Abstract]
90. Mashimo H, Wu C, Fishman MC, Podolsky DK. Protection and healing of intestinal mucosa: gene-targeted disruption of intestinal trefoil factor impairs defense of mucosal integrity. Gastroenterology 1996;110:A959 (abstr).
Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.
Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
Bioactive components for the treatment of gastroinstwestinal disorders Author(s): Ghosh S, Playford RJ. Clinical Science (London, England : 1979). 2003 June; 104(6): 547-56. Review.