Nonsteroidal antiinflammatory drug–induced gut injury - (NSAIDs)
About NSAIDs
Drugs like these are used worldwide to help with pain and inflammation caused by arthritis and many other musculoskeletal disorders and in conditions such as sinusitis, prostatitis and cystitis. The most prominent members of this group of drugs are aspirin, ibuprofen, and naproxen, partly because they are available over-the-counter in many areas.
Symptoms and side-effects
When they are used for longer periods of time, NSAIDs may cause side effects and complications ranging from micro-bleeding, ulcers in the gastrointestinal tract to liver and kidney toxicity. These drugs are anti-inflammatory and they do not promote healing. Stomach lining irritation is the common symptom for people taking NSAIDs , which can lead to increased gut permeability, gastrointestinal bleeding or ulcers.
How holvita™ colostrum can help with NSAIDs gut damage
Colostrum is a source of growth factors; growth factors have been shown to reduce gastro-intestinal injury in experimental and clinical studies. Growth factors help to reduce the permeability of the intestines by helping to regenerate and repair of the damaged intestinal cell wall and aid in maintaining the integrity of the gastrointestinal tract.
“Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug induced increase in intestinal permeability.”
Below is a study published by American Journal of Clinical Nutrition Vol. 72, No. 1, 5-14, July 2000.
"Nonsteroidal antiinflammatory drug–induced gut injury Nonsteroidal antiinflammatory drugs (NSAIDs) are widely prescribed and are effective in the treatment of musculoskeletal injury and chronic arthritic conditions. Nevertheless, 2% of subjects taking NSAIDs for 1 year suffer from gastrointestinal adverse effects, including bleeding, perforation, and stricture formation of the stomach and intestine (80). Acid suppressants and prostaglandin analogues have been shown to be effective in reducing gastric injury induced by NSAIDs but are less effective in preventing small intestinal injury. Novel therapeutic approaches to deal with these problems, such as the use of recombinant peptides, are therefore still required. A recent series of in vivo and in vitro studies support this idea; EGF (25) and TGF-
and TGF-ß (81) have all been shown to reduce NSAID-induced gastric injury".
The beneficial effects of recombinant growth factors on NSAID-induced small and large intestinal injury is, however, less well documented. It was shown recently that a defatted colostrum preparation, which is rich in the growth factors discussed earlier, reduced NSAID-induced gastric and intestinal injury in rats and mice (Figure 1) (81). This material was also shown to effectively reduce gastric erosions in human volunteers taking NSAIDs (J Hunter, personal communication, 1998). Further support for this approach comes from our recent finding that this defatted colostrum preparation reduced small intestinal permeability, which was used as a marker of intestinal damage in human volunteers taking clinically relevant doses of the drug indomethacin (82). Clinical trials involving patients taking NSAIDs long term are under way.
Our holvita™ colostrum will be very beneficial to people who are using NSAIDs to help with side effects of the drugs within the gastro-intestinal tract.
References
25. Playford RJ, Marchbank T, Calam J, Hansen FH. EGF is digested to smaller, less active, forms in acidic gastric juice. Gastroenterology 1995;108:92–101.[Abstract]
80. MacDonald TM, Morant SV, Robinson GC, et al. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study. BMJ 1997;315:1333–7.[Abstract/Full Text]
81. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID-induced gut damage. Gut 1999;44:653–8.[Abstract/Full Text]
82. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID-induced gut damage. Gut 1999;44:653–8.[Abstract/Full Text]
Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.
Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
Bioactive components for the treatment of gastroinstwestinal disorders Author(s): Ghosh S, Playford RJ. Clinical Science (London, England : 1979). 2003 June; 104(6): 547-56. Review.