English | Deutsch | Cesky

Colostrum references

In this section you can read and find all references and research that has been done with colostrum within the scientific field.

Allergies & Asthma

  • Subratty AH; Hooloman NK; Role of circulating inflammatory cytokines in patients during and acute attack of bronchial asthma. Indian J.Chest Dis Allied Sci 1998, Jan-Mar; 40[1]:17-21.
  • Staroscik, K. et al “Immunologically Active Nonapeptide Fragment of a Proline-Rich-Polypeptide from Bovine-Colostrum: Amino Acid Sequence and Immuno-regulatory Properties” Molecular Immunology (1983) Vol. 20(12), 1277-1282.
  • . Runa Ali, A. Barry Kay, Mark Larché, The Potential of Peptide Immunotherapy in Allergy and Asthma , Current Allergy and Asthma Reports 2001.
  • Drs. Tortora, Funke & Cast; Microbiology "Clinical studies show that IgE (Immunoglobulin), found in bovine colostrum, may be responsible for regulating allergic response."
  • Ogram Pearay, et. al., 1983, Annals of NY Academy of Sciences, 409, pp 82-92: “Colostrum Derived Immunity and Material Neonatal Interaction”: Peyer’s patches are found throughout the intestinal tract and groups of immunoactive cells like them are found in the bronchial mucosa. Both the intestinal and bronchial immunoactive cell groups respond to allergens, antigens, and pathogens by neutralizing or destroying them. In newborns, these special cell groups are not immediately operative but protection is provided by a variety of immune factors from the mother’s colostrum. Antibodies found in the colostrum protect against E.coli, Salmonella, Shigella, V. Cholera, Bacteriorides Fragilis, Streptococcus Pneumoniae, Bordtella Petussis, Clostridium diphtheria, Clostridium Tetani, Streptococcus Mutans and Candida Albicans.
  • Jackson, P. G., et al, 1981, Lancet, Vol l(8233) p 1285-6; 'Intestinal permeability in patients with eczema and food allergy.'
  • Galand, L. El al, 1993, J Adv Med, v 6 p 67-82; 'Intestinal dysbiosis and the causes of disease'. Tortora, Funke, Cast, 1982, Microbiology, Published by BenjaminiCumming pp. 403-405. " Specific defenses of the host: Immunology": B-cells of the immune system produce immunoglobulinslantibodies. The IgE (immunoglobulin) thought to be responsible for regulating allergic response. IgE found in Bovine colostrum.
  • Crago, Iblestecky, 1983, Survey of Immunology. Res., Vol. 2 No 2 pp. 164-169: "lmmunoinhibitory Elements in Human Colostrum": (A protein substance was found in colostrum which inhibits the overproduction of lymphocytes stimulated by antigens and mitogens and may reduce symptoms associated with allergic reactions.)
  • Janusz, Lisowski, 1993, Arch. Immunol. Ther. Exp. Warz. Vol. 41(5-6): 275-9 Report on clinical study: A. New immunomodulatory peptide found in bovine colostrum: Proline-Rich Polypeptide (PRP). B. Not Species specific (transferable to human use). C. PRP increases permeability of skin vessels. D. Causes differentiation of murine thymocytes into functionally active T cells. E. Simultaneously changes surface markers and function of cells. F. Results shown in treatment of auto-immune disorders and sarcoma S- 180 (cancer). G. Important immune modulator: stimulates underactive immune system, tones down an overactive one.
  • Collins, AM, et al. Bovine milk, including pasteurized milk, contains antibodies directed against allergens of clinical importance to man. International Archives of Allergy and Applied Immunology 96:362-367 (1991). The presence of antibodies against many of the most common allergies in man, including ryegrass pollen, house dust mites, Aspergillus mold and wheat gluten, were detected in bovine colostrum.
  • Delespesse, G. Polypeptide factors from colostrum. US Patent #5,371,073 (1994). IgE (the immunoglobulin involved in allergic response) binding factors (IgE-bf) and IgE suppressor activity (IgE-SF) obtained from colostrum have been successfully used to treat allergies
  • Keech, A.M., Peptide Immunotherapy: The Use of Bovine Colostrum Proline-Rich Polypeptides in Cytokine Modulation for the Alternative Relief of Allergic Symptoms. 2007 AAAAI Annual Meeting, San Diego, February 23-27 (to be published)
  • LeFranc-Millot C, Vercaigne-Marko D, Wal J. -M, et al. (1996) Comparison of the IgE titers to bovine colostral G immunoglobulins and the F(ab')2 fragments in sera of patients allergic to milk. Int Arch Allergy Immunol. 110:156-162.
  • Kamen, PhD, Betty; Kamen, MEng, Paul. 1998 CYTOLOG: INFOPEPTIDES; A POTENT, SAFE, BROADSPECTRUM THERAPEUTIC TOOL. Colostrum’s immune components contain the “information” required by the human immune system to identify and eliminate unfriendly biological pathogens.
  • "Clinical studies show that IgE (Immunoglobulin), found in bovine colostrum, may be responsible for regulating allergic response." Drs. Tortora, Funke & Cast; Microbiology
  • Subratty AH; Hooloman NK; Role of circulating inflammatory cytokines in patients during and acute attack of bronchial asthma. Indian J.Chest Dis Allied Sci 1998, Jan-Mar; 40[1]:17-21.
  • Ogram Pearay, et. al., 1983, Annals of NY Academy of Sciences, 409, pp 82-92: “Colostrum Derived Immunity and Material Neonatal Interaction”: Peyer’s patches are found throughout the intestinal tract and groups of immunoactive cells like them are found in the bronchial mucosa. Both the intestinal and bronchial immunoactive cell groups respond to allergens, antigens, and pathogens by neutralizing or destroying them. In newborns, these special cell groups are not immediately operative but protection is provided by a variety of immune factors from the mother’s colostrum. Antibodies found in the colostrum protect against E.coli, Salmonella, Shigella, V. Cholera, Bacteriorides Fragilis, Streptococcus Pneumoniae, Bordtella Petussis, Clostridium diphtheria, Clostridium Tetani, Streptococcus Mutans and Candida Albicans.
  • F. Runa Ali, A. Barry Kay, Mark Larché, The Potential of Peptide Immunotherapy in Allergy and Asthma , Current Allergy and Asthma Reports 2001.
  • "Clinical studies show that IgE (Immunoglobulin), found in bovine colostrum, may be responsible for regulating allergic response." Drs. Tortora, Funke & Cast; Microbiology

Chronic fatigue syndrome

Coeliac's disease

Hashimoto's thyroiditis

  • Staroscik, K. et al “ Immunologically Active Nonapeptide Fragment of a Proline-Rich-Polypeptide from Bovine-Colostrum: Amino Acid Sequence and Immuno-regulatory Properties” Molecular Immunology (1983) Vol. 20(12), 1277-1282.
  • Wieczorek, Z., et al “Proline-Rich-Polypeptide from bovine colostrum; its effect in skin permeability and on the immune response” Immunology, 1979; 36(4): 875-881.

Lupus

  • (2) Beth Ley, PhD; Immune System Control: Colostrum and Lactoferrin. ""Colostrum contains a special Proline-Rich-Polypeptide (PRP) that serves as a powerful regulator of the immune system. PRP in colostrum increases the permeability of the skin vessels, which offers a regulatory activity, stimulating or suppressing the immune response." (Staroscik)" 2000.
  • (3)By the Editors of The Doctors' Prescription for Healthy Living Magazine. The Colostrum Miracle: The Anti-Aging Super Food that can boost immunity and prevent premature aging. (2005) p74.
  • Dr. Zoltan Rona; "PRP from colostrum can work as a regulatory substance of the thymus gland. It has been demonstrated to improve or eliminate symptomatology of both allergies and autoimmune diseases (MS, rheumatoid arthritis, lupus, myasthenia gravis). PRP inhibits the overproduction of lymphocytes and T-cells and reduces the major symptoms of allergies and autoimmune disease: pain, swelling and inflammation."The American Journal of Natural Medicine, March 1998.
  • The Colostrum Miracle: The Anti-aging Super Food that can boost immunity and prevent premature aging. Authors: By the Editors of The Doctors' Prescriptions for Healthy Living Magazine) "PRP from colostrum can work as a regulatory substance of the thymus gland. It has been demonstrated to improve or eliminate symptomatology of both allergies and autoimmune diseases (MS, rheumatoid arthritis, lupus, myasthenia gravis). PRP inhibits the overproduction of lymphocytes and T-cells and reduces the major symptoms of allergies and autoimmune disease: pain, swelling and inflammation." --Dr. Zoltan Rona, The American Journal of Natural Medicine, March 1998.
  • "The ability to stimulate or suppress the immune response is highly significant. Suppressing the immune system is necessary to prevent the immune system from attacking the body itself, as in the case of autoimmune disease such as rheumatoid arthritis, lupus, MS, Alzheimer's disease and allergies. Colostrum's suppressive action may help prevent this type of activity involved in autoimmune diseases." --Beth Ley, PhD Nutrition 
  • Zimecki, M, Artym, J. [Therapeutic properties of proteins and peptides from colostrum and milk] Post?py Higieny i Medycyny Doswiadczalnej 59:309-323 (2005). Colostrum and milk are rich in peptides and proteins which play an active role in innate immunity. PRP has a variety of immunotropic functions, including the promotion of T cell maturation and inhibition of autoimmune disorders.
  • Kruzel ML, Boldogh I, Zimecki M; Lactoferrin in health and disease. Lactoferrin, an iron-binding glycoprotein, can be regarded as a cell-secreted mediator that bridges innate and adaptive immune function by regulating target cell response. It is a major pleiotropic mediator that directly assists in the development of T-helper cell polarization. The aim of this mini review is to provide a summActor JKary of the most recent work presented at the Lactoferrin Mini symposium at the University of Texas, Health Science Center at Houston, Texas, USA, regarding role of lactoferrin in maintaining immune homeostasis. The data presented here lay emphasis on the significance of lactoferrin in the resolution or progression of the immune responses, thus giving lactoferrin bookend properties in controlling the initial reactions to infectious assault, trauma, and injury. These findings may be critically important in the development of therapeutically relevant protocols. Department of Integrative Biology and Pharmacology, the University of Texas, Health Science Center at Houston, Texas 77030, USA. Postepy Hig Med Dosw (Online). 2007;61:261-7.
  • (Beth M. Ley, P.h.D; Immune system control: Colostrum and lactoferrin. 1969 (2000); p69-70.)

Multiple sclerosis

  • Basten, A, McLeod, JG, Pollard, JD, Walsh, JC, Stewart, GJ, Garrick, R, Frith, JA, Van Der Brink, CM. Transfer factor in treatment of multiple sclerosis. The Lancet 2(8201):931-934 (1980).
  • Dr. Zoltan Rona; "PRP from colostrum can work as a regulatory substance of the thymus gland. It has been demonstrated to improve or eliminate symptomatology of both allergies and autoimmune diseases (MS, rheumatoid arthritis, lupus, myasthenia gravis). PRP inhibits the overproduction of lymphocytes and T-cells and reduces the major symptoms of allergies and autoimmune disease: pain, swelling and inflammation." The American Journal of Natural Medicine, March 1998.
  • The Colostrum Miracle: The anti-aging super food that can boost immunity and prevent premature aging. 2005.
  • Ebina, T., et al. “Treatment of multiple sclerosis with anti-measles cow colostrum.” Med Microbiol Immunol (Berl), 1984;173(2):87-93.
  • amoureux, G, et al. Transfer Factor or Proline-rich Polyepetides from Bovine Colostrum: A clinical and immunological study of the effects of transfer factor on multiple sclerosis patients. Clin Exp Immunol. 1981 March; 43(3): 557–564.
  • Kelly, G."Bovine colostrums: a review of clinical uses" Altern Med Rev. 2003 Nov;8(4):378-94.. Webster. H.D. "Growth Factors and Myelin Regeneration in Multiple Sclerosis" Mult. Scler Apr. 3(2):113-120 1997.
  • Thapa BR; Therapeutic potentials of bovine colostrums “Colostrum is the first milk produced by mammals for their young ones. This transfers the passive immunity gained by the mother to the baby. The bovine colostrum (BC) can be obtained in large quantity and has properties similar to human colostrum. It has been used for various disorders of the body. It has properties to stimulate immune system, contains growth factors and many bioactive substances needed for the body to combat with wear and tear. The BC has been used for various gastrointestinal disorders, respiratory tract infection, rheumatoid arthritis, healing injured tissues of body etc. There are not much double blind placebo-controlled trials to prove its efficacy, though a lot of experience about its good effects in various disorders is available in the literature. The dosage and duration of therapy need to be worked up. The BC has potential to treat as well to prevent certain diseases in the body. In future this will prove to be a very useful product to treat and control diseases in a natural way.” Division of Pediatric Gastroenterology, Postgraduate Institute of Medical Education and Research Chandigarh, India. Indian J Pediatr. 2005 Oct;72(10):849-52.

Rheumatoid arthritis

  • Staroscik, K. et al. “Immunological ActivNona peptide Fragment of a Proline-Rich-Polypeptide from bovine colostrum; Amino And Sequence-and Immunoregulatory Properties” Molecular Immunology(1983) vol.20(121. 1277-1282.)
  • Zimecki, M, Artym, J. [Therapeutic properties of proteins and peptides from colostrum and milk] Colostrum and milk are rich in peptides and proteins which play an active role in innate immunity. PRP has a variety of immunotropic functions, including the promotion of T cell maturation and inhibition of autoimmune disorders.Post py Higieny i Medycyny Doswiadczalnej 59:309-323 (2005)
  • Kruzel ML, Actor JK, Boldogh I, Zimecki M; Lactoferrin in health and disease. Lactoferrin, an iron-binding glycoprotein, can be regarded as a cell-secreted mediator that bridges innate and adaptive immune function by regulating target cell response. It is a major pleiotropic mediator that directly assists in the development of T-helper cell polarization. The aim of this mini review is to provide a summary of the most recent work presented at the Lactoferrin Mini symposium at the University of Texas, Health Science Center at Houston, Texas, USA, regarding role of lactoferrin in maintaining immune homeostasis. The data presented here lay emphasis on the significance of lactoferrin in the resolution or progression of the immune responses, thus giving lactoferrin bookend properties in controlling the initial reactions to infectious assault, trauma, and injury. These findings may be critically important in the development of therapeutically relevant protocols. Department of Integrative Biology and Pharmacology, the University of Texas, Health Science Center at Houston, Texas 77030, USA. Postepy Hig Med Dosw (Online). 2007;61:261-7.
  • Thapa BR; Therapeutic potentials of bovine colostrums. Division of Pediatric Gastroenterology, Postgraduate Institute of Medical Education and Research Chandigarh, India. Indian J Pediatr. 2005 Oct;72(10):849-52.
  • Zimecki M, Kruzel ML. Milk-derived proteins and peptides of potential therapeutic and nutritive value. J Exp Ther Oncol. 2007;6(2):89-106. Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland.
  • Jenkins, R. T., et al, 1987, Br J Rheumatol, Vol 26(2) pl0-3-7; 'Increased intestinal permeability in patients with rheumatoid arthritis: a side effect of oral nonsteroidal anti-inflammatory drug therapy.'
  • Hayashida K, Kaneko T, Takeuchi T, Shimizu H, Ando K, Harada E. Oral administration of lactoferrin inhibits inflammation and nociception in rat adjuvant-induced arthritis. J Vet Med Sci. 2004 Feb;66(2):149-54. Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Japan.

Sjögren syndrome

  • Pedersen AM, Andersen TL, Reibel J, Holmstrup P, Nauntofte B. Clin Oral Investig. 2002 Mar;6(1):11-20. Related Articles, Links, Oral findings in patients with primary Sjogren's syndrome and oral lichen planus-a preliminary study on the effects of bovine colostrum-containing oral hygiene products. Department of Oral Physiology, Anatomy, Pathology and Medicine, School of Dentistry, University of Copenhagen, Denmark.
  • Groenink J, Walgreen-Weterings E, van 't Hof W, Veerman EC, Nieuw Amerongen AV. Cationic amphipathic peptides, derived from bovine and human lactoferrins, with antimicrobial activity against oral pathogens. FEMS Microbiol Lett. 1999 Oct 15;179(2):217-22. Department of Oral Biology, Section Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands.
  • Tenovuo J. Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety. Oral Dis. 2002 Jan;8(1):23-9. Institute of Dentistry and Turku Immunology Centre, University of Turku, Finland.
  • Tenovuo J, Lumikari M, Soukka T. Salivary lysozyme, lactoferrin and peroxidases: antibacterial effects on cariogenic bacteria and clinical applications in preventive dentistry. Proc Finn Dent Soc. 1991;87(2):197-208. Department of Cariology, University of Turku, Finland.
  • Tenovuo J. Antimicrobial function of human saliva--how important is it for oral health? Acta Odontol Scand. 1998 Oct;56(5):250-6. Institute of Dentistry and Turku Immunology Centre, University of Turku, Finland.
  • Human saliva contains a number of physical physicochemical, and chemical agents that protect oral tissues against noxious compounds, in particular those produced by various microorganisms. Among such protective factors, the flushing effect of saliva flow is the most important one, not only because it so effectively removes exogenous and endogenous microorganisms and their products into the gut but also because a steady supply of saliva guarantees continuous presence of both non-immune and immune factors in the mouth. A great number of studies with controversial results have been published regarding various individual agents and their possible association to oral health, particularly to dental caries. It appears that no single chemical agent is far more important than the others. For example, patients with selective IgA deficiency have normal levels of non-immune defense factors and often display a compensatory increase in the other immunoglobulin isotypes. The concerted action of all agents in whole saliva, both saliva- and serum-derived, provides a multifunctional protective network that is collapsed only if salivary flow rate is substantially reduced. In this mixture of defense factors, many show additive or even synergistic interactions against oral pathogens. Increased knowledge of the molecular functions of various agents has made it possible to prepare oral hygiene product that include host-derived antimicrobial agents instead of synthetic agents. Although the clinical efficacy of such products is still unsatisfactory and poorly described, new technologies, for example in the production of specific antibodies against oral pathogens, may considerably improve the antimicrobial power of these products.