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Colostrum references

In this section you can read and find all references and research that has been done with colostrum within the scientific field.

Colitis

  • Lissner R; Schmidity H; Karch H; A standard immunoglobulin preparation produced from bovine colostrum shows antibody reactivity and neutralization activity against Shiga-like toxins and EHEC-hemolysin of Escherichia coli 0157:H7 Biotest Pharma GmbH, Dreieich, Germany, Infection 1996, Sep-Oct-;24[5]:378-83
  • Dluholucky, S et. Al., 1980, Archives of Disease in Childhood, 55, pp 458-460; 1980; Antimicrobial activity of colostrums after the administration of inactive Escherichia Coli oral vaccine to expectant mothers: Mothers developed immune factors that develop on mucosal sources that enter blood serum and concentrate in expectant mothers’ mammary glands. Describes how colostrums may develop immunities.
  • Bitzan MM; et al, J Infect Dis. April 1998. Inhibition of Hilicobacter pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. Results indicate confirmation that colostrum can prevent infection of Helicobacter species bacteria.
  • Spik, Genevive, et. al. 1983, Immunology, Vol. 35 No 4 pp. 663-670: "Bacteriostasis of a milk-sensitive Strain of E. coli by lmmunoglobulins and Iron-binding Proteins in Association": French doctors showed that a combination of IgG and Lactoferrin in colostrum was bacteriostatic for E. coli.
  • Dial, Elizabeth J.; et. al. Gastroenterology, 87; 379-85, 1984 A role for Milk Phospholipids in Protection Against Gastric Acid (Studies in Adult and Suckling Rats). Findings suggest that milk contains potent anti-ulcer activity.

Crohn's disease

  • Zimecki M; Spiegel K; Wlaszczyk A; Cheneau P; Brunel A; et al; Immunoregulatory effects of a nutritional preparation containing bovine lactoferrin taken orally by healthy individual. Institute of Immunology and Experimental Therapy, Polish Academy of Sciences,Wroclaw, Poland. Arch Immunol Ther Exp [Warsz] 1998;46[4]:231-40.
  • Ishiguro Y; Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis. J Gastroenterol 1999 Feb;34[1]:66-74
  • Oz, HS, Ray, M, Chen, TS, McClain, CJ. (2004) Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease. Journal of the American College of Nutrition 23(3):220-6. Mice with an experimentally-induced inflammatory bowel disease fed a diet rich in transforming growth factor beta-2 (TGF-ß2) gained more weight, did not develop diarrhea or prolapse, had lower pathological scores and lower serum amyloid (SAA). This study supports the use of TGF-ß2 diets in the treatment of Crohn’s disease.
  • Pironi, L., et al, 1990, Dig Dis Sci, Vol 35(50 p 582-8; 'Relationship between intestinal permeability and inflammatory activity in asymptomatic patients with Crohn's disease.'

Irritable bowel syndrome

  • Petschow BW; Talbott RD; Batema RP;Ability of lactoferrin to promote the growth of Bifidobacterium spp.in vitro is independent of receptor binding capacity and iron saturation level. J.Med Microbio 11999 Jun;48[6]:541-9
  • 77. Playford RJ, Boulton R, Ghatei MA, Bloom SR, Wright NA, Goodlad RA. Comparison of the effects of TGF and EGF on gastrointestinal proliferation and hormone release. Digestion 1996;57:362–7.[Medline]
  • 78. O'Loughlin W, Winter M, Shun A, et al. Structural and functional adaptation following jejunal resection in rabbits: effect of epidermal growth factor. Gastroenterology 1994;107:87–93.[Abstract]
  • Oz, HS, Ray, M, Chen, TS, McClain, CJ. (2004) Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease. Journal of the American College of Nutrition 23(3):220-6. Mice with an experimentally-induced inflammatory bowel disease fed a diet rich in transforming growth factor beta-2 (TGF-ß2) gained more weight, did not develop diarrhea or prolapse, had lower pathological scores and lower serum amyloid (SAA). This study supports the use of TGF-ß2 diets in the treatment of Crohn’s disease.
  • Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
  • Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
  • Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.
  • Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
  • Bioactive components for the treatment of gastroinstwestinal disorders Author(s): Ghosh S, Playford RJ. Clinical Science (London, England : 1979). 2003 June; 104(6): 547-56. Review.

Inflammatory bowel disease

  • 87. Procaccino F, Reinshagen M, Hoffman P, et al. Protective effect of epidermal growth factor in an experimental model of colitis. Gastroenterology 1994;107:12–7.[Abstract]
  • 88. Porter SN, Howarth GS, Butler RN. An orally administered growth factor extract derived from bovine whey suppresses breath ethane in colitic rats. Scand J Gastroenterol 1998;33:967–74.[Medline]
  • 89. Zeeh JM, Procaccino F, Hoffmann P, et al. Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. Gastroenterology 1996;110:1077–83.[Abstract]
  • 90. Mashimo H, Wu C, Fishman MC, Podolsky DK. Protection and healing of intestinal mucosa: gene-targeted disruption of intestinal trefoil factor impairs defense of mucosal integrity. Gastroenterology 1996;110:A959 (abstr).
  • Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
  • Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
  • Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.
  • Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
  • Bioactive components for the treatment of gastroinstwestinal disorders Author(s): Ghosh S, Playford RJ. Clinical Science (London, England : 1979). 2003 June; 104(6): 547-56. Review.
  • Oz, HS, Ray, M, Chen, TS, McClain, CJ. (2004) Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease. Journal of the American College of Nutrition 23(3):220-6. Mice with an experimentally-induced inflammatory bowel disease fed a diet rich in transforming growth factor beta-2 (TGF-ß2) gained more weight, did not develop diarrhea or prolapse, had lower pathological scores and lower serum amyloid (SAA). This study supports the use of TGF-ß2 diets in the treatment of Crohn’s disease.

Leaky gut

  • Deitch, MD, FACS, Edwin A., Arch. Surg,. 1990, Vol 125, The role of Intestinal Barrier Failure and bacterial Translocation in the Development of Systematic Infection and Multiple organ failure. “...increasingly clear that the gastrointestinal tract is not a passive organ...” “... the GI track recognized as having important endocrine, metabolic, immunologic and barrier functions...” “...bacteria/ednotoxin escaping from the gut could lead to systematic infection and disease...” “...studies indicate that one or more three basic pathophysiologic factors appear to be necessary for bacterial translocation to occur.” “Three promoting factors are disruption of the ecologic balance of the... microflora, resulting in overgrowth with certain bacteria, impaired host immune defences, and physical disruption of the gut mucosal barrier.”
  • Galland, M.D., FACN, Leo, 1995, Townsend Letter for Doctors, Aug.-Sep. Leaky Gut Syndromes: Breaking the Vicious Cycle. “Leaky Gut Syndromes are usually provoked by exposure to substances which damage the integrity of the intestinal mucosa...causes of damage are infectious agents (viral, bacterial and protozoan), 43-46 ethanol, 47-47 and NSAIDs. 20, 49, 50 Hypoxia of the, 51,52 elevated levels of reactive oxygen metabolites, 53 and cytotoxic drugs 54-56 also increased para-cellular permeability.” “Altered intestinal permeability is a key element in the pathogenisis of many different diseases. Hyperpermeability initiates a pancreatic insufficiency and malnutrition occur; each of these increased leakiness of the small bowel. Effective treatment of the Leaky Gut Syndromes requires several components: avoidance of enterotoxic drugs, and allergic foods, elimination of infection or bacterial overgrowth with antimicrobial ad probiotics, and dietary supplementation with trophic nutrients.
  • Bjarnason, I. Et al, 1984, Lancet, Vol i p 79-82' The leaky gut of alcoholism: the route of entry for toxic compounds'.

NSAIDs

  • 25. Playford RJ, Marchbank T, Calam J, Hansen FH. EGF is digested to smaller, less active, forms in acidic gastric juice. Gastroenterology 1995;108:92–101.[Abstract]
  • 80. MacDonald TM, Morant SV, Robinson GC, et al. Association of upper gastrointestinal toxicity of non-steroidal anti-inflammatory drugs with continued exposure: cohort study. BMJ 1997;315:1333–7.[Abstract/Full Text]
  • 81. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID-induced gut damage. Gut 1999;44:653–8.[Abstract/Full Text]
  • 82. Playford RJ, Floyd DN, Macdonald CE, et al. Bovine colostrum is a health food supplement which prevents NSAID-induced gut damage. Gut 1999;44:653–8.[Abstract/Full Text]
  • Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
  • Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
  • Playford RJ, Floyd DN, Macdonald CE, Calnan DP, Adenekan RO, Johnson W, Goodlad RA, Marchbank T., Gut. 1999 May;44(5):653-8. Related Articles, Links, Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. University Division of Gastroenterology, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK. Pluske, JR, Morel, PCH. Increasing weaner pig productivity in New Zealand pig herds. Factors associated with grower herd performance in three New Zealand pig farms (1999). Piglets fed a liquid supplement with colostrum powder had a marked increase in villi height in the lumen of the small intestine, indicating greater digestion and absorption of nutrients. There were also an increased number of immune cells in the villi, indicating enhanced immune competency.

Chemo induced Mucositis

  • 83. Hirano M, Iweakiri R, Fujimoto K, et al. Epidermal growth factor enhances repair of rat intestinal mucosa damaged after oral administration of methotrexate. J Gastroenterol 1995;30:169–76.[Medline]
  • 84. Sonis ST, Lindquist L, Van Vugt A, et al. Prevention of chemotherapy-induced ulcerative mucositis by transforming growth factor beta 3. Cancer Res 1994;54:1135–8.[Abstract]
  • 85. Howarth GS, Francis GL, Cool JC, Ballard RW, Read LC. Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats. J Nutr 1996;126:2519–30.[Medline]
  • 86. Gordler NM, McGurk M, Aqual S, Prince M. The effect of EGF mouthwash on cytotoxic-induced oral ulceration. Am J Clin Oncol 1995;18:403–6.[Medline]
  • Waldman, et. al., 1983, Annals of NY Academic Science, Vol. 409, 510-515: Reported the intestinal tract is lined with mucous membranes. Researchers at West Virginia University School of Medicine and Pharmacy stated: “Most infectious diseases enter the body through or remain localized on mucosal surfaces.” Waldman stated: “that this means in order to be healthy, we must be able to combat disease causing organisms where most of them attack us; which is on the mucous membranes of the intestinal tract.” (This is where colostrum does most of its work)
  • Service, Science, Sept 9, 1994 v 265 p 1522-4: Research News: Triggering the First line of Defence: “Vaccines that activate the mucosal immunity, the bodies first chance to ward off infection, are hard to come by. Situation changing new vaccines are needle free. Mucosal surfaces turn out 70% of our body’s antibodies. Has been virtually ignored. Mucosal system most important area to concentrate attention in prevention of disease. New vaccines developed to be delivered orally. IgA very effective in picking up invaders before they gain entry. Studies prove that vaccines made with pathogens that infect animals can confer protection to human.”
  • Hanson, et.al., Annals of NY Academy of Sciences, 409, 15ff: “Mucosal Immunity”: The immune system produces immunoglobulins, antibodies, leukocytes, macrophages, interferon and other factors for defending the body. Immune factors from specialized cell groups in the bronchials and bowel travel away from their sources to coat the passages of the lungs and bowels and destroy antigens, allergens and pathogens. Immune factors from colostrum other than immunoglobulins blocked attachment of many types of bacteria to mucus membranes. Oligosaccharides (big sugar molecules) from colostrum blocked attachment of Steptococcus pneumonococci, a major cause of lung inflammations and middle ear infections.
  • Deitch, MD, FACS, Edwin A., Arch. Surg,. 1990, Vol 125, The role of Intestinal Barrier Failure and bacterial Translocation in the Development of Systematic Infection and Multiple organ failure. “...increasingly clear that the gastrointestinal tract is not a passive organ...” “... the GI track recognized as having important endocrine, metabolic, immunologic and barrier functions...” “...bacteria/ednotoxin escaping from the gut could lead to systematic infection and disease...” “...studies indicate that one or more three basic pathophysiologic factors appear to be necessary for bacterial translocation to occur.” “Three promoting factors are disruption of the ecologic balance of the... microflora, resulting in overgrowth with certain bacteria, impaired host immune defences, and physical disruption of the gut mucosal barrier.”
  • Kim, JW, Jeon, WK, Yun, JW, Park, DI, Cho, YK, Sung, IK, Sohn, CI, Kim, BI, Yeom, JS, Park, HS, Kim, EJ, Shin, MS. (2005) Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. Asia Pacific Journal of Clinical Nutrition 14(1):103-7
  • Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
  • Eldridge, et. al. 1983, Annals of NY Academy of Sciences, 409, pp 819-821. “Peyer’s Patches accessory Cells Bear I-1”: Groups of cells in the mucosa of the intestinal tract, known as Peyer’s patches produce and absorb immune factors.

Peptic ulcers

  • Bitzan MM; Gold BD; Phillpott DJ; et al; Inhibition of Helicobacteria pylori and Helicobacter mustelae binding to lipid receptors by bovine colostrum. J Infect Dis 1998 Apr; 177[4]:95506d1.
  • Kivinen, Anneli; S. Salminen; et. al. Milchwisser schaft, 47(9), 1992. Gastroprotective effect of milk phospholipids, butter serum lipids and butter serum on ethanol and scetylsalicylic acid induced ulcers in rats. Phospholipids in cow milk protect the GI tract from ulcers.
  • Playford RJ, Macdonald CE, Johnson WS; American Journal of Clinical Nutrition, Vol. 72, No. 1, 5-14, July 2000. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders.
  • Dial EJ.; Hall LR; Serna H; Romero JJ; Fox JG; Lichtenberger LM; Antibiotic properties of bovine lactoferrin on Helicobacter pylori. Department of integrative biology, The University of Texas- Houston Medical School. Dig Dis Sci 1998 Dec: 43[12]: 2750-6.
  • Purup, S, Vestergaard, M, Pedersen, O, Sejrsen, K. (2007) Biological activity of bovine milk on proliferation of human intestinal cells. Journal of Dairy Research 74(1):58-65. Bovine milk contains a number of biologically active components that affect growth development of human intestinal tissue. The degree of activity depended on the stage of lactation.
  • Walker, W. A,, 1975, Pediatr Clin. Norfh Am., Vol 22(4) p 731-46; 'Antigen absorption from the small intestine and gastro-intestinal disease'
  • Khazenson, L. B., 1980, Microbial & Epidemial Immunobiology No. 9 p 101-106. In 1980 Dr. L.B Activity of bovine colostral IgG in the human digestive tract. Khazenson and assoc.’s completed a study on human volunteers in which cow colostrum was taken orally. Samples of their digestive tract demonstrates that the immune factors were effective in providing protection. They concluded: “The preservation of the biological activity of IgG (immunoglobulin) in the digestive secretions of adults receiving bovine immune colostrum orally indicates – passive enternal (intestinal) immunization for the prevention and treatment of acute intestinal diseases”

Short Bowel syndrome

  • 77. Playford RJ, Boulton R, Ghatei MA, Bloom SR, Wright NA, Goodlad RA. Comparison of the effects of TGF and EGF on gastrointestinal proliferation and hormone release. Digestion 1996;57:362–7.[Medline]
  • 78. O'Loughlin W, Winter M, Shun A, et al. Structural and functional adaptation following jejunal resection in rabbits: effect of epidermal growth factor. Gastroenterology 1994;107:87–93.[Abstract]
  • 79. Kelly D, King TP, McFadyen M, Coutts AGP. Effect of preclosure colostrum intake on the development of the intestinal epithelium of artificially reared piglets. Biol Neonate 1993;64:235–44.[Medline]
  • Krysiak R, Gdula-Dymek A, Bednarska-Czerwinska A, Okopien B. Growth hormone therapy in children and adults. Pharmacol Rep. 2007 Sep-Oct;59(5):500-16.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, PL 40-752 Katowice, Poland.
  • Playford RJ, Boulton R, Ghatei MA, Bloom SR, Wright NA, Goodlad RA. Comparison of the effects of transforming growth factor alpha and epidermal growth factor on gastrointestinal proliferation and hormone release. Digestion. 1996;57(5):362-7.