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Colostrum references

In this section you can read and find all references and research that has been done with colostrum within the scientific field.

Cold and Influenza

  • Cesarone, MR, Belcaro, G, Di Renzo, A, Dugall, M, Cacchio, M, Ruffini, I, Pellegrini, L, Del Boccio, G, Fano, F, Ledda, A, Bottari, A, Ricci, A, Stuard, S, Vinciguerra, G. (2007) Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Clinical and Applied Thrombosis/Hemostasis 13(2):13-6. Two month supplementation with oral colostrum was compared to anti-influenza vaccination in the prevention of flu. Colostrum was at least three times more effective than vaccination in preventing flu.
  • Aabakken. Lam.; short term effect of bovine colostrum in patients with throat angina. A placebo controlled study. Statistical Report No. 309, Vuramed. Norway. Norges Apatekares tidsskritt, 98 nr 22. April 1990.
  • Urban, T. The Oponizing ability in antibodies from some healthcare products containing bovine colostrum. State Laboratory, State Phanaceutical Company. Stokholm. Swedish Phanaceutical Asociation. Yearly Congress 1990.
  • Shortridge, KF, Lawton, JW, Choi, EK. Protective potential of colostrum and early milk against prospective influenza viruses. Journal of Tropical Pediatrics 36(2):94-95 (1990).
  • Rump JA, Arndt R, Arnold A, Bendick C, Dichtelmuller H, Franke M, Helm EB, Jager H, Kampmann B, Kolb P, et al. Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clin Investig. 1992 Jul;70(7):588-94.
  • Palmer, E.L ET., 1980, Journal of Medical Virology. 5 pp 123-129. “Antiviral activity of Colostrum and Serum Immunoglobulins A and G.” Colostrum has an enteric secretory virus antibody that acts against virusal invaders. A wide range of antiviral factors were acknowledged to be present in colostrums. This research was done in the US Government’s Center for Disease control in Atlanta, Georgia.

Herpes

  • Rouse, B.T. et.al., 1976, Infection and Immunity, 13, pp. 1433. Antibody-dependent Cell-Mediated Cytoxtoxicity in Cows: Comparison of Effector Cell Activity Against Heterologous Erthrocyte and Herpes-Virus-Infected Bovine Target Cells: "Bovine leukocytes have antibody dependent cell-mediated cytoxciity against bovine herpesvirus." Bovine Colostral cells with antibody were able to kill cells infected with herpes simplex in vivo.
  • Kohl,S. et.al., 1978, Journal of Clinical Laboratory Immunology, 1, pp. 221-224. "Human Colostral Cytotoxicity: Antibody-Dependent Cellular Cytotoxicity Against Herpes Simplex-Infected Cells Mediated by Colostral Cells ": Colostral cells along with antibody were found to destroy herpes simplex-infected cells.
  • Isaacs, et. a1.,1995, Science, April p.p. 231: "Reporting in Experimental Biology "95: teams confirmed colostrum delivers not just antibodies but a battery of infection fighting agents. Among them, retinoic acids a Vitamin A derivative. Dr. Charles E. lsaacs et. al. at New York State Institute for Basic Research on Staten Island, NY, infected culture cells with herpesvirus, his findings were that only retinoic acids conferred protection and reduced colonization. He concluded that while ratinoic acids were not a cure, it effectively reduced the herpes virus to levels ( 11100 to 1/10,000 viruses remained active after treatment ) where the bodies immune system could fight off an outbreak.
  • Hasegawa, K, et al. Inhibition with lactoferrin of in vitro infection with human herpes virus. Japanese Journal of Medical Science and Biology 47:73-85 (1994). Both human and bovine lactoferrin inhibit infection with human herpes simplex virus and human cytomegalovirus in cell cultures.

Hepatitis C

  • Abe K, Nozaki A, Tamura K, Ikeda M, Naka K, Dansako H, Hoshino HO, Tanaka K, Kato N. Tandem repeats of lactoferrin-derived anti-hepatitis C virus peptide enhance antiviral activity in cultured human hepatocytes. Microbiol Immunol 2007;51(1):117-25. Department of Molecular Biology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan. (Link)
  • Ikeda M, Sugiyama K, Tanaka T, et al. (1998) keda M, Sugiyama K, Tanaka T, et al. (1998) Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes.Biochemical and biophysical research communications 245:549-553. (Link)
  • Ikeda M, Nozaki A, Sugiyama K, Tanaka T, Naganuma A, Tanaka K, Sekihara H, Shimotohno K, Saito M, Kato N. Characterization of antiviral activity of lactoferrin against hepatitis C virus infection in human cultured cells. Virus Res. 2000 Jan;66(1):51-63. Virology and Glycobiology Division, National Cancer Center Research Institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan. (Link)

HIV/AIDS

  • Jage, Kampmann, Kolb, et. al., 1992, Clin. Instigation Jul.; 70(7): 588-94 Reported: A. Immunoglobulins from bovine colostrum (lactobin, biotest, Dreieich, FGR) contains high titres of antibodies against a wide range of bacterial, viral, and protazoa pathogens, as well as against various bacterial toxins. B. Colostrum quite resistant to gastric acids. C. Effective in the treatment of intestinal opportunistic infections associated with HIV and other immunosurpressed disease.
  • "lmmnoglobin to Prevent Nosocomial Infections" New England Journal of Medicine, July 23, 1992, Vol 327 No 4 p 269. lmmunoglobulin from bovine colostrum effective in reducing and preventing infections in immune deficient subject: bone marrow recipients, premature babies, AIDS, etc. Problem: obtaining high and consistent levels of functional antibodies though donor selection. Could improve through pooled selection, selective donor immunization, and addition of monoclonal antibodies.
  • Jage, Kampmann, Kolb, et. al., 1992, Clin. Investigation Jul.; 70(7): 588-94 Reported: A. immunoglobulins from bovine colostrum (lactobin, biotest, Dreieich, FRG) contain high titres of antibodies against a wide range of bacterial, viral and protozoa pathogens, as well as against various bacterial toxins. B. Lactobin quite resistant to gastric acids. C. Effective in the treatment of opportunistic infections that cause diarrhea. Treatment and effectiveness in AlDS patients verified, where no other treatment was effective. Rump, et. al., 1992, Clinical Investigator, Vol. 70 pp. 588-94: Treatment of Diarrhea in AlDS and bone marrow transplant patients with Bovine Colostrum: Reported colostrum quite resistant to gastric juice. Oral treatments very effective. No side effects.
  • Deseret News, SLC, Utah, Apr 6, 1995: Component of Human Milk Blocks HIV infection: "Research reported in the March issue of the Journal Of Nutrition by David Newburg of the Harvard Medical School, reported a component called chondroitin sulfate blocks the binding of HIV to its host cell receptor. This could limit the postnatal transmission of HIV in breast fed infants of HIV infected mothers.
  • Nowa, McMichael, Scientific American, Aug 1995 p58-65. How HIV defeats the immune System: " Continuous and dangerous evolution of HIV virus underlies body and medical sciences inability to find means to defeat. Vaccines not effective, virus mutates too quickly and there are too many mutant variations. Reducing viral levels in the body and stimulating natural immune capabilities have the most promise to help natural immune system contain the virus.
  • Stephan, W, et al. Antibodies from colostrum in oral immunotherapy. Journal of Clinical Chemistry and Clinical Biochemistry 28:19-23 (1990). An immunoglobulin preparation from pooled bovine colostrum was found to be very effective in treating severe diarrhea, such as often found in AIDS patients.
  • Pizza, G, Chiodo, F, Colangeli, V, Gritti, F, Raise, E, Fudenberg, HH, De Vinci, C, Viza, D. Preliminary observations using HIV-specific transfer factor in AIDS. Biotherapy 9(1-3):4-47 (1996). 25 HIV infected patients at various stages (CDC stages II-IV) were treated with HIV-specific transfer factor (PRP) for periods of 60-1870 days. All patients were receiving antiviral treatment as well. Clinical improvement or a stabilized clinical condition was observed in 20 of the 25, and 12 of 14 anergic patients showed restored delayed hypersensitivity reactions to recall antigens within 60 days. Treatment was well-tolerated and appears beneficial to AIDS patients.
  • Plettenberg, A, et al. A preparation from bovine colostrum in the treatment of HIV-positive patients with chronic diarrhea. Clinical Investigator 71(1):42-45 (1993).
  • Rump, J. A.; Aarndt, R.; Arnold, A.; Bendick, C.; Dichtelmuller, H.; Franke, M.; Helm, E. B.; Jager, H.; Kampmann, B.; Kolb, P.; et al. “Treatment of Diarrhoea in Human Immunodeficiency Virus-Infected Patients with Immunoglobulins from Bovine Colostrum” Clin Investig. 70(7):588-594,(1992).
  • Unger, B. L. P.; et al. “Cessation of Cryptosporidium-Associated Diarrhea in AIDS Patients After Treatment with Hyperimmune Bovine Colostrum” Gastroenterology. 98:486-489, 1990.
  • Zimecki, M, Artym, J. [Therapeutic properties of proteins and peptides from colostrum and milk] Post?py Higieny i Medycyny Doswiadczalnej 59:309-323 (2005). Colostrum and milk are rich in peptides and proteins which play an active role in innate immunity. PRP has a variety of immunotropic functions, including the promotion of T cell maturation and inhibition of autoimmune disorders.

Rotavirus

  • Petschow and Talbott, 1994, Journal of Pediatric Gastroenterologic Nutrition. Aug.; 1912) pp. 228-235. Bovine colostrum immunoglobulin concentrates proposed for incurring passive immunity against various enteric pathogens. Reports on specific bovine colostrum viral immunofactors for rotavirus partially reduced by gastric acid. Suggest reduction of gastric acid and pancreatic trypsin would enhance immunoprophylaxis (effectiveness).
  • Ebina, et. al., 1983, The Lancet, Vol. 29 No 2 pp. 1029-1030: "Prevention of Rotavirus Infection By Cow Colostrum Containing Antibody Against Human Rotavirus": Japanese researchers exposed cattle to oral doses of rotavirus which causes severe diarrhea and bowel inflammation in humans. Colostrum from these cows contained antibodies which, when fed to humans, prevented them from getting rotavirus.
  • Sarker SA, Casswall TH, Mahalanabis D, Alam NH, Albert MJ, Brüssow H, Fuchs GJ, Hammerström L. Successful treatment of rotavirus diarrhea in children with immunoglobulin from immunized bovine colostrum. Pediatr Infect Dis J. 1998 Dec;17(12):1149-54. International Centre for Diarrhoeal Diseases Research, Dhaka, Bangladesh. (Link)
  • Brüssow, H., et al. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. Journal of Clinical Microbiology 25(6):982-986 (1987). Protection against rotavirus, a dangerous pathogen which can cause serious, even fatal diarrhoea in infants, can be passed orally through milk or colostrum safely and effectively.
  • Davidson GP; et. al. The Lancet, Sept. 23, 1989 p. 709-712. Passive Immunisation of Children with Bovine Colostrum Containing Antibodies to Human Rotavirus. In a 10-day controlled study: Children fed bovine colostrum did not get rotavirus while 13.8% of those who were fed an artificial infant formula acquired the virus.
  • Ushijima et. al., Dept. Of Enteroviruses, Japanese National Health Institute, Mar, 1990 V64(3)p 274-9: Immunoglobulin components and anti viral activities in bovine colostrum: IgG, IgM, IgA were found in bovine colostrum, anti-human adenovirus antibody was not found. Oral treatment rotavirus gastroenteritis found to be effective” (Rotavirus is the leading cause of diarrhoea in the world)