holvita™ colostrum supports recovery from injury
holvita™ colostrum can help athletes who have been injured to heal and return to training as quickly as possible. Downtime for athletes affects their physical performance and fitness. So if an athlete can return from injury as quickly as possible it is very beneficial. Colostrum contains beneficial components that encourage the body to heal itself and regenerate quicker.
holvita™ Colostrum can help athletes with:
Cell and tissue repair growth factors have regeneratory effects on bones, tissue damage, cartilage, tendons and muscle strains.
Bone injuries (fractures)
Bone injures are serious problems for athletes as they take long time to heal. When injury occurs and bone s completely fractured tendons, muscles and other cells around the affected area are damaged, they degenerate and die. The body then starts a repair process:
The three main stages of healing are:
- Reactive Phase where the fracture fracture occurs inflammation starts due to the cell damage. After this granulation tissue formation takes place ( fibroblasts survive and will start to replicate, they form loose cells and small blood vessels) Fibroblasts (FgFs) are essential for the regulation of bone formation.
- Reparative Phase, days after a fracture periostal cells and form into chondroblasts and start to form cartilage. Periostal cells then start to form into osteoblast and form woven bone. Fibroblasts within the granulation tissue also form into chondroblasts and these two new tissues grow in size until they unite with the other pieces of the fracture. Then a phase of cartilage replacement starts, eventually, all of the woven bone and cartilage of the original fracture is replaced by new trabecular bone, restoring much, if not all, of the bone's original strength.
- Remodelling Phase in which the trabecular bone is replaced by compact bone and the trabecular bone is reabsorbed by osteoclasts. Osteoblast then deposit compact bone and eventually the fracture is remodelled into a new shape which closely duplicates the original shape.
The main growth factors involved in cell and tissue regeneration are:
- Insulin-like growth factor-I & II (IgF-I & II)
- Epidermal growth factor (EgF)
- Transforming growth factor (TgF)
- Platelet-derived growth factor (PdgF)
- Fibroblast growth factor (FgF)
- Growth Hormone (GH)
All of these are found in holvita colostrum.
IgF-I and IgF-II growth factors are critically important in all aspects of bone physiology, regulating bone growth and development, remodeling and repair. The growth factors in colostrum can help to quickly repair the damage, regenerative effects of colostrum extend to nearly all structural cells of the body. Transforming growth factors A & B (TgF A & B) also found in colostrum are known for their ability to enhance healing and take part in the synthesis and repair of both RNA and DNA. Other growth factors EgF and PDgF are also capable of stimulating cell division and tissue development.
Cartilage and tendon damage
Key factors in colostrum also help with the repair of tendons and cartilage. Growth factors
- Platelet-derived growth factor (PDgF)
- Fibroblast growth factor (FgF)
- Insulin like growth factor (IgF-I)
- Transforming growth factor (TgF)
Are most important when repairing connective tissue. Cartilage has very limited repair capabilities because chondrocytes (cells that repair damaged cartilage tissue) cannot easily get to the effected areas and start to create new connective tissues. Usually the cartilage is replaced by fibrocartilage scar tissue. Normal cartilage expresses insulin-like growth factor-I (IgF-I), basic fibroblast growth factor (bFgF) and transforming growth factor-b (TgFb) and these seem to be the most important local regulators of chondrocyte (cells found in cartilage) function.
Our holvita colostrum contains all key growth factors and therefore it could help athletes with cartilage and tendon damage recovery.
References
Seyedin, Thompson, Sentz, et. al., 1986, Journal of Biol. Chemistry, Vol. 261, pp. 5693-95: Reported Cartilage Inducing Factor-A in colostrum and its apparent affinity to Transforming Growth Factor B (in human and bovine colostrum), and its relationship to cartilage repair.
Bricker, BS, Daniel S. The American Chiropractor, Nov. 1991. COLOSTRUM: Implications for Accelerated Recovery in Damaged Muscle and Cartilage, Prevention of some Pathogenic Disease. Bovine colostrum contains unsurpassed repair characteristics for muscle and cartilage.
Cartilage Inducing Factor-A, found in colostrum, stimulates cartilage repair. Drs. Seyedin, Thompson, Bentz, et. al.; Journal of Biological Chemistry
Goldberg A. Effects of growth factors on articular cartilage. The Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK. Ortop Traumatol Rehabil. 2001 Apr 30;3(2):209-12.
Muscle strains/tears
Muscle strain is damage caused by over stretching of the muscle tissue. Muscle tissue becomes overloaded and reaches a breaking point.
A muscle strain is damage caused by over-stretching of muscle tissue. The muscle tissue becomes overloaded and reaches a breaking point where a tear or partial tear occurs.
When a muscle injury occurs the process of healing begins with an inflammatory response which usually last for few days. It is very important to rest and protect the injured part in order to prevent further damage and allow the body to continue with the healing process. During the period of inflammation the body produces chemicals and cells which start to remove the damaged dead cells and muscle fibres and begin the repair process.
The repair process involves three stages:
1. REGENERATION OF MUSCLE FIBRES
Within the muscle new cells that form the fibres start to grow.
2. FORMATION OF SCAR TISSUE
In the gap between the torn muscle ends, there is bleeding and from this blood new tissue will start to grow and form a bridge that attaches the torn muscle ends. This offers protection against any further damage.
3. MATURATION OF THE SCAR TISSUE
The collagen fibres that make up the scar tissue becomes aligned and are able to withstand more force.
The rehabilitation after this period involves gradually stretching the muscle to elongate the scar tissue and progressively increasing the muscle strength. Once this has been achieved, the player can begin sport-specific exercises, such as running, jumping and kicking. To reduce the risk of re-injury, this should be done under the supervision.
The most important factors in the three steps of healing are growth factors. Growth factors found in colostrum can help the body to repair injured muscles by replacing the damaged muscle fibres quicker. Growth factors are made of short protein chains called polypeptides that play key regulatory roles in cell growth, replication and differentiation. Specific growth factors are not only able to improve muscle regeneration but can also encourage more complete muscle healing. IgF-I and b-FgF can accelerate healing and higher functional recovery. Growth factors can help the muscle to regenerate and strengthen quicker with better quality of healing.
By enhancing muscle growth and regeneration by growth factors contained in colostrum it is possible to avoid the formation of scar tissue, caused by injury between, normal muscle and reduce the risk of re-injury. Growth factors and other components in our holvita™ colostrum promote have positive effect on muscle healing.
References:
Tollefsen, Lajara, McCusker, Clemmons, 1989, Journal of Biological Chemistry, Vol. -264 No 23, Aug. 15: " Insulin-Like Growth Factors (IgF) in muscle Development": IgF's role in differentiation, repair, synthesis, and their interplay with other necessary growth factors. IgF-I only factor that can stimulate muscle growth and repair by itself. Eliminates catabolism and stimulates anabolism at the cellular level.
Tollefsen, Sherida E, et al. 1989, The Journal of Biological Chemistry, Vol. 264, No 23, August 15, Insulin-like Growth Factors (IGF) in Muscle Development. "...Studies demonstrate that several components critical to IGF action are produced in a a fusing skeletal muscle cell line in a differentiation-dependent manner and suggest that both IGF-1 and IGF-2 may be autocrine factors for muscle."
Bricker, BS, Daniel S. The American Chiropractor, Nov. 1991. COLOSTRUM: Implications for Accelerated Recovery in Damaged Muscle and Cartilage, Prevention of some Pathogenic Disease. Bovine colostrum contains unsurpassed repair characteristics for muscle and cartilage.